National Toxicology Centre (NTC)

The National Toxicology Centre (NTC), a state-of-art test facility is constructed on an area of 700 sq. meters. established for toxicity studies of new chemical entities, food / feed additives / Pharmaceuticals / Chemicals / Pesticides from industries and other research organizations. The National GLP Compliance Monitoring Authority from Dept. of Science and Technology, Govt. of India New Delhi approved National Toxicology Centre (NTC) for conducting various toxicological studies. This has facilitated the testing of new chemical entities for regulatory submission in a quality environment which is acceptable to different regulatory bodies. Till now we have successfully completed many studies of national and international origin. We are routinely conducting acute and sub-chronic studies on small laboratory animals for sponsors which are from both public and private sector.

Dedication

This facility is dedicated to small animals who sacrifice their lives for the betterment of mankind *Partially funded by DPR Programme from DST, GOI, New Delhi
(First Govt. test facility approved by National GLP Compliance Monitoring Authority (NGCMA), DST, New Delhi)

Infrastructure:

The National Toxicology Centre (NTC) is designed on a concept of clean and dirty corridor and has six state-of-art animal rooms including two quarantine rooms. The Centre is also equipped with the individual ventilated caging system and metabolic cages. The centre is having an in vitro facility for screening of new chemical entities (NCEs).

Quality Assurance Office:

A full fledged Quality Assurance Unit (QAU) is in place to monitor all the activities of the Centre.

Archive Section

There are two Archive sections present in the test facility for proper storage of different kinds of study related dry and wet materials. There are two fire proof cabinets available in the Archives for the storage of important documents. The facility is also having well equipped necropsy room.

There are three Laboratories:

Biochemistry and hematology Laboratory:
It is equipped with modern instruments like hematoanalyser validated for veterinary use, Sophisticated Spectrophotometer (Flex station) with a facility to use ELISA plates, Shimadzu HPLC, Olympus microscope with attached computer and provision for taking high resolution photographs and Refrigerated Centrifuge.
The Centre is having 275 SOPs and 222 log books for different activities and instruments.

Histopathology Laboratory:
This laboratory is equipped with Automated tissue processor and stainer units, microtome and paraffin embedding unit for routine histopathology work.

Genotoxicity Laboratory:
In vitro laboratory
The laboratory is fully equipped for conducting cytotoxic studies.

 

Test Item Control Office (TICO):

There is an independent TICO for the receipt, maintenance and further distribution of test item.

Organizational Structure:

Head, Management   

Director NIPER SAS Nagar

 

Management       

Prof. K.B. Tikoo

 

Study Directors / Study Personnel          

Dr. GB Jena

Ms. Rupinder Pal Kaur

Ms. Nidhi

Mr. Sharath S Babu

Ms. Vibha Ahuja
Mr. Vinod Kumar

 

Quality Assurance Unit

Ms. Kanwaljit Kaur

Dr. Malti Singh

 

Veterinarian

Dr.K. Srinivasan

 

Test Item Controller

Mr. Shantaram R. Bhade

Mr. Vijay Mishra

 

Archivist  and Archive Staff

Mr. Shantaram R. Bhade

Mr. Sanjeev Bhardwaj

Mr. Vijay Mishra

 

Statistician

Dr. Pooja Arora

 

Pathologist

Dr. B.N. Dutta

 

Capabilities:

The facility can undertake the following studies under the principles of Good Laboratory Practice (GLP) for testing of New Chemical Entities (NCEs) in small laboratory animals.

  • Acute Toxicity Study

  • Repeated dose toxicity Study

This facility can also take the following non-GLP studies:

  • Toxicokinetic study

  • Toxicogenomic study

  • In vitro cytotoxicity study

  • Genotoxicity study

  • Nanoparticle toxicity study

  • Permeability study using Caco-2 cell lines

Genotoxicity Screening using Metasystem : The fast Msearch metaphase finding software, running with scanning hardware platform Metafer, helps to vastly increase the throughput in routine toxicological screening. Micronuclei in bi-nucleated cells and comet scan can be efficiently carried out on the same platform with specified platform with specified software.

Toxicogenomic Screening: Major changes during the next decade is expected ,as new technologies and knowledge become incorporated into regulatory and industrial practices. Evaluation of toxicological profile using DNA microarray are being used to predict the toxicity of NCEs early in the preclinical processes.

Toxicity Screening of nanoparticles: The rapidly developing field of nanotechnology is a potential source of toxicity through inhalation, ingestion, skin uptake and injection of engineered nanomaterials. Information about the safety and potential hazards is urgently needed. NIPER has been conducting projects on nanoparticles toxicity.

Inhalation toxicity Testing: The test facility is equipped with state-of ľart inhalation exposure system (CH Technologies, California) for nose only exposure to both mice and rats.

Certification of GLP Compliance:

 

Glimpse of some Important Events / Visitors:

Instruments / Facilities Available:

 

 

Page Last Updated / Reviewed on: 29-May-2019

|Archives| About this Site| Terms of Use | Content Review Policy | Hyperlink Policy |Internet Access Policy| Sitemap| Help |

|Copyright@ NIPER S.A.S. Nagar |Feedback: Webmaster |  Disclaimer |