Central Facilities

A large number of sophisticated equipment and advanced facilities/centres are available at NIPER S.A.S. Nagar. A few of the major ones are listed below:

Central Instrumentation Laboratories (CIL)

The central instrumentation laboratories are equipped with major instruments like 400 MHz  NMR, 300 MHz NMR, GC-MSⁿ,  GCMS , Head Space GC, LC-MSⁿ, Powder XRD,  MALDI TOF-TOF  MS, FTIR with ATR & microscope , UV-VIS spectrophotometers, CHNS-Elemental analyzer, Polarimeter, Circular Dichroism,  Atomic Absorption Spectrophotometer, Analytical and preparative HPLC systems, DSC, TGA, Spectroflourimeter, Capillary Electrophoresis, Lyophilizer and Ultra Centrifuge etc.

Each department also has a separate specialized instrument laboratory to fulfil individual departmental needs based on the research programs, which includes high and normal pressure multiple organic synthesizer, peptide synthesizer, gel permeable chromatography, hydrogenation reactors, photoreactor, microwaves reactor, GC and HPLC systems, protein purification system, HPTLC, MPLC, spray dryer,  lyophilizer, polygraph, stimulator, auto analyser, blood cell counter, tissue processor and embedding set-up, freeze microtome, spheronizer & extruder, Glatt multi-purpose coater, Neocota, inverted and upright microscopes, humidity and thermostatic chambers, automated dissolution apparatus, laser particle size analyzer, incubator shaker, electrophoresis and immunoblot apparatus, gel dryer, imaging densitometer, microelectroeluter, stirred cell microconcentrator, steritest system, scintillation counters, rotapress, fluidized bed dryer, capsule filling machine, strip packing machine, ampoule/vial washing and filling machines, tube filling machine, sparkler filter, multimill and colloid mill.

To find the more information please visit the webpage of Central Instrumentation Laboratories.

Central Animal Facility (CAF)

National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar as an establishment is registered with Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Ministry of Environment, Forest & Climatic Change, Government of India for the Research for education, Research for the commercial purpose, Breeding for in-house use and Breeding for the purpose of trading of small laboratory animals (108/GO/Re/Rc/Bi/Bt/99/CPCSEA).The Central Animal Facility (CAF) is the double storied building with ‘Two-way corridor system’ to minimize the cross contamination and for the efficient animal house operations. The first floor is dedicated to the breeding of different small laboratory rodents like mice, rats, hamsters, gerbils and guinea pigs for the supply to the various in-house and consultancy research projects. The animals are also supplied on request to the outside CPCSEA registered establishments on stipulated terms and conditions. Each animal species is housed separately in individual room to prevent inter-species disease transmission and anxiety due to interspecies conflict. The animals are well _selftained under controlled environmental conditions (temperature (23+3°C), relative humidity (30-70 %), 12:12 h light and dark cycle with 100 % of fresh air exchange in animal rooms. The macro- and micro-environment around the animals are _selftained as per the CPCSEA guidelines. In addition to the breeding unit, there is a separate experimental unit available for the holding and conducting the experiments on animals. Full time veterinarian is available to provide veterinary care to the animals. A high degree of personal hygiene and sanitation is being practiced. Regular cleaning and disinfection of animal rooms, corridors, storage spaces and other areas are carried out. Routine cleaning and sterilization of animal supplies like cages, water bottles and bedding are performed. Horizontal heavy duty autoclave is installed for the sterilization purpose and regularly monitored for its effectiveness of operations. Periodic health monitoring of the animals is carried out. In addition, feed and water analysis are carried out for ensuring their quality and microbiological contamination. Waste disposal is carried out through incinerator. The routine works at CAF are carried out as per the standard operating procedures adopting GLP principles to achieve the quality production and supply of the experimental animals.
  

To find the more information please visit the webpage of Central Animal Facility.

Computer Aided Drug Design Laboratory

The Computer Aided Drug Design Laboratory of the Institute has Silicone Graphics Octane and Silicone Graphics Fuel _self frame computers with various molecular modeling packages such as SYBYL, PC SPARTAN PRO, CHEM-X, AMBER, Gaussain 98, Protein Data Bank, and Alchemy etc. The objective of this laboratory is to rationally design new chemical entities for various therapeutic areas. The laboratory also imparts training in molecular modeling to scientist, research students from other universities/Institutes.

Combichem Research Laboratory

The Institute has recently created a Combichem Research Laboratory. The fully automated Multiple Organic Synthesiser with on-line analytical facility will enable high speed solution and solid phase synthesis of libraries of molecules. The multiple vessel reaction platforms make the synthesis feasible under various conditions such as low temperature (upto -80°C), high temperature (upto 200°C), and high pressure. Apart from its own research needs, the Institute makes this facility open for custom synthesis of small molecule libraries and training researchers from pharmaceutical companies and other institutions/organisation.

Peptide Synthesis and Research Laboratory

NIPER has recently created state-of-the-art solid phase peptide synthesis facility. The peptide synthesis is carried out on a fully automated CSBIO-136 peptide synthesizer by a team consisting of expert peptide chemists. The facility is capable of synthesizing up to 12 amino acids containing peptide in 24 hours by using both t-Boc and Fmoc peptide synthesis protocols. Institute is open to inquiries related to custom peptide synthesis from various pharmaceutical companies, research institutes and agencies interested in peptides for research.

National Toxicology Centre (NTC)

The National Toxicology Centre (NTC), a state-of-art test facility is constructed on an area of 700 sq. meters. established for toxicity studies of new chemical entities, food / feed additives / Pharmaceuticals / Chemicals / Pesticides from industries and other research organizations. The National GLP Compliance Monitoring Authority from Dept. of Science and Technology, Govt. of India New Delhi approved National Toxicology Centre (NTC) for conducting various toxicological studies. This has facilitated the testing of new chemical entities for regulatory submission in a quality environment which is acceptable to different regulatory bodies. Till now we have successfully completed many studies of national and international origin. We are routinely conducting acute and sub-chronic studies on small laboratory animals for sponsors which are from both public and private sector.

This facility is dedicated to small animals who sacrifice their lives for the betterment of mankind *Partially funded by DPR Programme from DST, GOI, New Delhi
(First Govt. test facility approved by National GLP Compliance Monitoring Authority (NGCMA), DST, New Delhi
 

To find the more information please visit the webpage of National Toxicology Centre.

SCFE is an environmental friendly approach for extraction of natural products/herbals. The ever increasing strict environmental regulations for use of common industrial solvents, most of which are hazardous to human health, have led to the popularity and growth of SCFE technologies employing supercritical CO2 as a solvent (has accepted status as GRAS). Sophisticated SCFE instrumentation allows precise regulation of changes in temperature and pressure and thus manipulating solvating property of SCF which helps the extraction of natural products of wide polarities.
Natural Products Field Laboratory, Department of Natural Products, at the institute is equipped with following two SCFE systems:
--SCFE Lab Scale
--SCFE Pilot Scale
 

To find the more information please visit the webpage of SCFE Facilities

Pharmacological and Toxicological Screening Facilities

The Institute can carry out :

• Pharmacological screening of NCE’s 
• Safety pharmacology
• in vivo Mutagenicity
• in vitro Cell proliferation and cytotoxicity
• Radio-receptor binding assays and
• Regulatory toxicological testing viz, acute and subchronic toxicity testing.

Small and Medium Pharmaceutical Industry Centre (SMPIC)

Department of Pharmaceuticals, Government of India announced the setting up of a dedicated centre for Small and Medium Pharmaceutical Industries (SMPIs) at Pharmaceutical Advisory Forum (PAF) on 23rd April 2008. SMPIC came into existence from 23rd February, 2009. This centre aims at creating commercial synergy between industry and academia, and for furthering the spirit of cooperation.

To find the more information please visit the webpage of SMPIC.

National Bioavailability Centre (NBC)

The National Bioavailability Centre of the Institute is capable of conducting bioequivalence studies in healthy human volunteers. The centre has 24 bedded air conditioned volunteer room, a dining hall with attached kitchen, doctor's room, two sample collection rooms and a sample processing room. It has analytical laboratory equipped with  sophisticated equipments required to carry out the in vitro and in vivo analysis of samples. Already many industrial projects have been completed and many more are planned. The centre has been accredited by WHO and is one of the two centres in the world for conducting bioequivalence studies of the fixed dose combination (FDC) formulations of antitubercular drugs. The centre, in close collaboration with hospitals around Chandigarh, is also involved in conducting pharmacokinetic studies in patient population.

Find the more information of National Bioavailability Centre (NBC).

Or Download Training Brochure of National Bioavailability Centre (NBC).

Technology Development Centre (TDC)

NIPER undertakes sponsored projects for the development of economically viable processes for bulk pharmaceutical chemicals of synthetic or natural products origin, conventional and novel dosage forms.

NIPER SAS Nagar is the only institute in India which is having the Pharmaceutical Formulation manufacturing Pilot plant facility i.e. Technology Development Centre (TDC) - Dosage form (Formulation) at institute level.
The facility is designed and built as per the current Good Manufacturing Practices required for OSD manufacturing (Grade D/ISO class 8). The facility is having of 200 kg batch size capacity with buildup area of 24102 sqft.

To find the more information please visit the webpage of Technology Development Centre.

Pharmaceutical Heritage Centre (PHC)

The Pharmaceutical Heritage Centre was established with an objective to cater information on the development of our health care system from the ancient system to the current era of pharmaceuticals; to acquire specimens, archival materials related to the subject; and to preserve, study, document, interpret and exhibit the collections in a systematic manner.
The Centre is actively engaged in continued enrichment of its collection which usually involves visit to the site as well as the procurement of the actual specimen, books/equipments/testing gadgets/portraits/artifacts of heritage value and related to the development of pharmaceutical/medical/biomedical sciences in any part of the country.
The Centre is open for visitors from all sections of life including students to appraise them of the importance of the exhibits, collections, and to educate and inspire the public on the country’s rich heritage on the subject.

Click for more information of Pharmaceutical Heritage Centre.

Computer Centre (CC)

The Computer Centre caters to the needs of faculty, staff and students for their research and teaching. Computer Centre manages and administers high performance computing, named as PharmaGrid. This facility created at NIPER, S.A.S. Nagar is the central facility to establish a nationwide grid for carrying out pharmaceutical research with cutting edge technology. In the first phase, high performance computing facility was created with 192 cores cluster on linux, 64 cores cluster on windows platform and two 16 cores SMP servers. The aggregate compute power of the facility is 3.56 Tflops and the data storage capacity is over 15 Terabytes. The facility will work on all the major aspects of bioinformatics and chemoinformatics viz. genome analysis, sequence analysis, protein structure prediction, QSAR, molecular modeling, molecular dynamics and quantum chemical analysis. To facilitate these, various commercial and free software are available like Discovery studio, pipeline pilot, Amber, CPMD, Gaussian, GROMACS, NAMD, MATLAB, StarDrop, VASP, RDBMS (SQL server, Oracle) and Compilers (C, C++, , VC++, Visual Basic, Visual Java, FORTRAN etc.).
In addition to the HPC, Computer Centre has a general purpose computational lab with more than 60 high-end desktops. The various software available are ChemOffice, Pallas, SPSS, SigmaStat, SigmaPlot, Endnote, Acrobat Suit most of the popular Microsoft products like Office 2007/2003/XP/2000, Visual studio, SQL server etc.
Computer Centre also manages and administers other services such as DTP and helps the Institute community by managing computing resources which are available centrally or in various departments.
A campus-wide gigabit-ethernet local area network (LAN), which uses fiber optic media, makes computing services available across campus. Centre is also equipped with 1 Gbps dedicated internet connectivity allowing users to have access to the email, Internet and ScienceDirect™. Faculty and students can use internet, email and computing resources of the Institute from their residences/hostels by dialling through a modem or using the ADSL routers.
The Centre houses eight servers and several computer systems manufactured by IBM/Dell/Compaq/Acer. Computer Centre also supports high speed, network color laser printer, black & white laser printers, color plotter and scanners.
The Computer Centre has developed few databases and customized software for various applications.

Library and Information Centre

The Library & Information Centre has been developed and maintained to support the curricular and research needs of NIPER research fraternity.
The Library is housed in a four floored building:
Ground Floor: Acquisition & Circulation Section, Current Journals Section, Raj-Bhasha collection - Collection in Hindi Language, Computer systems for Users, Lounge area for reading newspapers and magazines.

First Floor: Reference Section, User System for Online access to Library Catalogue, Book Section, Documentation Unit, archives of old Journals (L to W), Newspaper Archive.

Second Floor: Reading area and archive of old Journals (A to K).

Third Floor: Chemical Abstracts, Thesis & Dissertation Section, Committee Hall

To find the more information please visit the webpage of Library and Information Centre.