Area of Interest:

Eukaryotic and prokaryotic cell division, microtubule dynamics, mitosis, cancer chemotherapy, FtsZ assembly dynamics, and FtsZ targeted antibacterial drugs and biomolecular spectroscopy

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Designation:

Professor & Head, Medicinal Chemistry

• Orghanic Synthesis (computationaly designed molecules)

• Medicinal Chemistry: Anti-malarial, anti-diabetic

• Nitreones: Synthesis, Bonding, Biology, Catalysis

• Quantum Medicinal Chemistry

• Pharmacoinformatics: Programming, data management

• Drug Metabolism, Drug Toxicity, Drug delivery--computational

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Medicinal chemistry, Peptide chemistry

• Synthesis and mechanistic studies of ultra short neuropeptides, antimicrobial peptides, and antiplasmodial peptides

• C-H and C-N functionalization of natural and unnatural amino acids

• Backbone modification of peptides by C-H and C-N functionalization

• Sustainable peptide synthesis

• Synthesis and mechanistic studies of unnatural amino acids

• Synthesis of new structural classes of antiplasmodial and anti-tuberculosis agents

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Patient safety, pharmaceutical care, geriatric pharmacotherapy, Pharmacovigilance, Pharmaco-economics, antimicrobial usage, clinical pharmacy, Pharmacotherapeutics, Rational use of drugs, Clinical Pharmacy, Good Pharmacy Practice.

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• Pharmaceutical Pre-formulation and material characterization
• Physico-chemical characterization, Polymorphism, pseudo-polymorphism, Molecular understanding of amorphous form, Salt form selection, Compaction physics, Surface characterization of pharmaceuticals, Permeability studies
• Solubility enhancement technologies
• 'Stabilization' of amorphous form using solid dispersions, Co-crystals
• Nanotechnology in drug delivery
• Small molecule assisted nano-crystallization, Nano-crystalline solid dispersions, Self nano-emulsifying drug delivery systems
• Particle engineering
• Co-processing to improve physico-technical properties
• Formulation development of novel and conventional drug delivery systems, Development of lyophilization cycle
• De-formulation studies to aid development of generic products

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• Epigenetics and Diseases
• Toxicant - induced mechanism of Cell-Death
• Nanotoxicology

Technologies Available

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Evaluation of Pharmacological Interventions Targeting Pathophysiological Cascades (Oxidative stress, PARP, ER stress, Inflammation, apoptosis) Involved in Stroke (Cerebral Ischemia), Diabetes, Diabetic Complications (neuropathy, encephalopathy & cardiomyopathy), Cognitive impairment (associated with Parkinson’s disease/Stroke) and Neuropathic Pain.

Elucidation of Pharmacological Potential of NCEs in Disease Models for Efficacy Studies

Safety Pharmacological Studies (Core, Follow up and Supplemental SPS) of NCEs

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Screening of plant extracts and their isolates (using bioassay-directed fractionation) for COX-2/COX-1 inhibitory activity which may be helpful as the leads for development of safer anti-inflammatory drugs with minimum side effects; design and synthesis of COX-2 inhibitors based on natural products; design and synthesis of microsomal Prostaglandin E₂ Synthase (mPGES)-1 inhibitors as novel anti-inflammatory agents; evaluation of synthesized compounds for anti-inflammatory activity in vitro using other molecular targets such as cytokines, TNF-α, IL-1 (IL-1 α  and IL-1β) and IL-6; evaluation of most bioactive compounds/lead molecules for anti-inflammatory activity in vivo; bioassay guided isolation and characterization of potential antimycobacterial natural products, discovery of bacterial efflux pump inhibitors from  medicinal plants; antioxidant, and anti-diabetic natural products; standardization of herbal drugs and formulations.

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Bioassay-guided isolation and structure elucidation of biologically active compounds from medicinal plants and microorganisms in therapeutic areas of HIV, leishmaniasis and cancer.
Design and biomimetic synthesis of bioactive molecules and their analogs for evaluation as anti-HIV, anti-leishmanial, anti-malarial, anti-cancer and antimicrobial agents.
Standardization of traditional Ayurvedic/herbal formulations.

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Area of Interest:

Data mining and pattern recognition:

• Application of machine learning and statistical methods to identify the pattern in biological data and chemical data

• Relational database development

• Software Development

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Regulatory Toxicology
To understand the toxicity of chemicals (NCEs, Pharmaceuticals and pollutants) and the principles of regulatory compliance. To evaluate different toxicity end-points using regulatory test guidelines and GLP principles. To establish and validate new test model development, test integration as well as to resolve issues & awareness in different gray areas of toxicology.
 

DNA damage, autophagy and carcinogenesis
Quantification of DNA damage using different bio assays (CA, MN, COMET) and molecular targets (Nrf2, P53, NF-kB)
 

Correlation between different levels (tissue, cell, DNA, somatic vs germinal, transplacental vs neonatal) of organizations and end- points of evaluations for determination of assay sensitivity and specificity.
To Explore new areas (germinal, intestinal and neuronal) for DNA damage detection and the influence on autophagy for different target organs of clinical significance.
 

Chemical intervention in Pathological Models
Exacerbation and amelioration of chemical toxicity (DNA damage, cell proliferation, fibrosis and germ cell damage) under Diabetic (Type I and II) condition. To understand the influence of trace elements, vitamins & inflammation in DNA damage, and cellular senescence.
 

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Development of Protein Biopharmaceuticals
i.)  Engineering Proteins with Improved Therapeutic Properties (Efficacy, Pharmacokinetic, Site-targeting, etc)

ii.)  Development of Industrial Feasible Process for the Production of Engineered Proteins

iii.) Biological characterization (in vitro and in vivo) of Engineered Proteins

Technologies Available

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Synthetic Organic Medicinal Chemistry

• Anticancer drug discovery: Design and synthesis of heterocyclic compounds as human DNA topoisomerase IIα inhibitors, Microtubule-dynamics inhibitors, DNA polymerases inhibitors, and their SAR studies
• Antileishmanial drug discovery: Design and synthesis of heterocyclic compounds as target-specific antileishmanial agents
• Network-linked polypharmacology-based drug discovery
• Natural product-inspired, Scaffold-hopping, and Choice-based change medicinal chemistry strategies
• Creating new from clinical trial agents and drugs; Exploration of patentable bioactive chemotypes
• Identification of target-specific unique pharmacophore motifs
• Structural modulations linked to pharmacodynamics, drug-likeness and pharmacokinetic-relevant physicochemical properties
• Synthesis of natural product-based compounds (structural elaborated, simplified and analog)
• Synthetic methodology development: Construction of pharmaceutically-privileged heterocyclic molecular skeletons, SAR/molecular diversity-enabled approach
• Chemistry: C-H bond functionalization, Ylide chemistry, Synthon, Isocyanide-based reactions, Catalysis, Green chemistry

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Host-Pathogen interaction during Infection
The emergence of drug resistant strains of tuberculosis has contributed to the fact that Mycobacterium tuberculosis remains one of the most successful pathogens. Research has been initiated in the area of host –pathogen interaction using cell biology and recombinant DNA based approaches. The main focus is on identifying multifunctional housekeeping enzymes of the host and pathogen that could be essential in the process of infection and survival of intracellular M.tuberculosis. In addition, a screening assay for anti-mycobacterials is also being developed. Other areas of interest are Iron metabolism and Immune signalling

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Area of Interest:

Broad Area: Advanced drug delivery using nanotechnology (Nanomedicine)

• Multifunctional nanocarriers for targeted drug delivery

• Improvement in oral bioavailability of drugs

• Topical and transdermal drug delivery

• Gene and vaccine delivery

• Lipid drug/ polymer drug conjugates

• Caco-2 cell based and ex-vivo permeability assay

• Intracellular Trafficking of nanoparticles

Google Scholar: http://scholar.google.co.in/citations?hl=en&user=aFapK-8AAAAJ

Leishmania donovani, sirtuins and Leishmania metabolism, Leishmanial MAP kinases, signal transduction in macrophages, drug targets, drug resistance.

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Phase I-Phase IV clinical trials, BABE studies, Pharmacovigilance, Neuropathic Pain studies,
Antimicrobial usage

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Synthetic organic, Process chemistry, Synthesis of compounds with anti-diabetic activity, Process chemistry involving therapeutically important  agents, Scale up of new synthetic processes, GMP regulations and Plant Management

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• Generation of benzyl and acyl radicals, radical cations largely using persulfates, especially their reactions in water, mechanistic study to understand their generation, umpolung reactivity of reactive radical intermediates, and their applications to the synthesis of heterocycles and generic active pharmaceutical ingredients (APIs)

• Understanding organic chemistry of drug degradations and interactions

• New process development for the synthesis of generic drugs and drug intermediates (APIs) utilizing novel catalytic C-H functionalizations, Tandem/Domino/Cascade reactions, or via C-H bond activation

• Design and synthesis of biaryl sulfonamides, atropisomerism in biaryl sulfonamdies, preparation of sultams and their ring opening via thermal or photochemical reactions, chemo-enzymatic ring opening of sultams

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• Mechanisms of peripheral nerve disease and identification of new therapeutic approaches
• Mitochondrial pharmacology and neurodegenerative diseases
• Diabetes and Diabetic complication (neuropathy and nephropathy) research
• Mechanism of Pain pathology in Drug and Trauma induced neuropathy
• In vitro and In vivo experimental models for efficacy and toxicity studies
• Extracellular Vesicles and disease pathologies

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• Intra-thymic development of T cells during cancer
• Intratumoral plasticity among T cell subtypes
• Influence of immune system in regulating cancer stem cells
• Analyzing non-hematopoetic stromal cells from immunological perspective
• Influence of type1 diabetes on cancer
• Immune regulation of MDR in NHL
• Analyzing Antitumor and immunomodulatory potential of Neem leaf glycoprotein
• Development of vaccine for cancer

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• Stability testing of the new and existing drug substances

• Impurity profiling

• Identification of degradation product and degradation pathway of the new drug substances

• Omics studies

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