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National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar. National Toxicology Centre* *Partially funded by DPR Programme from DST, GOI, New Delhi |
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"This facility is dedicated to small animals who sacrifice their lives for the betterment of the mankind..." |
About Us
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The institute
has the first Government test facility approved by National GLP
Compliance Monitoring Authority (NGCMA), DST, New Delhi
(https://dst.gov.in/ngcma). |
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Infrastructure
The National Toxicology Centre (NTC) is designed on a concept of clean and dirty corridors and has six state-of-art animal rooms including two quarantine rooms. The Centre is also equipped with the individual ventilated caging system and metabolic cages. The centre is having an in vitro facility for screening of new chemical entities (NCEs).
Quality Assurance Unit
Archive Section
There are following laboratories:
Biochemistry and Hematology Laboratory
It is equipped with modern instruments
like hematoanalyser validated for veterinary use, Sophisticated
Spectrophotometer (Flexstation) with a facility to use ELISA plates,
Shimadzu HPLC, Olympus microscope with attached computer and provision
for taking high resolution photographs and Refrigerated Centrifuge.
The Centre is having around 250 SOPs and 230 log books for different
activities and instruments.
Histopathology Laboratory
This laboratory is equipped with automated tissue processor and stainer units, microtome and paraffin embedding unit for routine histopathology work.
Test Item Control Office (TICO)
Capabilities
The facility can undertake the following studies under the principles of Good Laboratory Practice (GLP) for testing of New Chemical Entities (NCEs) in small laboratory animals.
- Acute Toxicity Studies
- Sub-acute toxicity Studies and
- Chronic toxicity Studies
- Toxicokinetic study
- Toxicogenomic study
- In vitro cytotoxicity study
- Genotoxicity study
- Nanoparticle toxicity study
- Permeability study using Caco-2 cell lines
Genotoxicity Screening using Metasystem: The fast Msearch metaphase finding software, running with scanning hardware platform Metafer, helps to vastly increase the throughput in routine toxicological screening. Micronuclei in bi-nucleated cells and comet scan can be efficiently carried out on the same platform with specified software.
Toxicogenomic Screening: major changes during the next decade is expected, as new technologies and knowledge become incorporated into regulatory and industrial practices. Evaluation of toxicological profile using DNA microarray are being used to predict the toxicity of NCEs early in the preclinical processes.
Toxicity Screening of nanoparticles: The rapidly developing field of nanotechnology is a potential source of toxicity through inhalation, ingestion, skin uptake and injection of engineered nanomaterials. Information about the safety and potential hazards is urgently needed. NIPER has been conducting projects on nanoparticles toxicity.
Inhalation toxicity Testing: The test facility is equipped with state-of –art inhalation exposure system (CH Technologies, California) for nose only exposure to both mice and rats.
Organizational Structure
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Head, Management |
Director, NIPER
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Management |
Prof. K.B. Tikoo
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Study Directors / Study Personnel |
Dr. G.B. Jena Ms. Rupinder Pal Kaur Ms. Nidhi Mr. Sharath S Babu Ms. Vibha Ahuja
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Quality Assurance Unit |
Ms. Kanwaljit Kaur Dr. Malti Singh
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Veterinarian |
Dr. K. Srinivasan
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Test Item Controller |
Mr. Shantaram R. Bhade Mr. Vinod Kumar
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Archivist and Archive Staff |
Mr. Shantaram R. Bhade Mr. Sanjeev Bhardwaj Mr. Vinod Kumar
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Statistician |
Dr. Pooja Arora
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Pathologist |
Dr. B.N. Dutta
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Contact Us
National Toxicology Centre (NTC),
National Institute of Pharmaceutical Education and Research (NIPER)
Sector-67, S.A.S Nagar, Punjab-160062.
Tel: +91-172-2292219. 2292153
E-mail: ntc[at]niper.ac.in